Acetonitrile → HCID 86733458, compound

Participants

Reaction Conditions

Reaction Steps

In 80 volume parts of acetic acid are dissolved 19 parts of TRH monohydrate and 7.5 parts of L-tartaric acid, and while the solution is warmed to 50°C, 240 volume parts of acetonitrile is added in installments. The temperature is gradually brought down to room temperature, at which temperature the solution is allowed to stand overnight. The resultant crystals are harvested by filtration, washed with acetonitrile and dried under reduced pressure. The procedure yields 25.7 parts of TRH tartrate-acetonitrile as crystals melting at 145°C-148°C. [α]D22 =-47.1° (c=1.0 in water)

Provenance & Evidence