Sodium Hydroxide → Viloxazine

HRID 1076965Notes

Reaction equation

HRID 1076965 reaction equation
Cl.[CH2:2]([O:4][C:5]1[CH:18]=[CH:17][CH:16]=[CH:15][C:6]=1[O:7][CH2:8][CH:9]1[O:14][CH2:13][CH2:12][NH:11][CH2:10]1)[CH3:3].[OH-].[Na+]>O>[CH2:2]([O:4][C:5]1[CH:18]=[CH:17][CH:16]=[CH:15][C:6]=1[O:7][CH2:8][CH:9]1[O:14][CH2:13][CH2:12][NH:11][CH2:10]1)[CH3:3]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 71424Viloxazine hydrochloride

Product 1

HCID 5666Viloxazine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

Citric and B.P. (0.5 g.) is dissolved in water for injection (75 ml.) and 2-(o-ethoxyphenoxymethyl)morpholine hydrochloride (2.36 g.) is added slowly to this solution with stirring. The pH of the solution is adjusted to 5.0 with N/l sodium hydroxide solution, the volume is made up to 100 ml. with water for injection and the pH is rechecked. The solution is filtered through a 5μ millipore membrane, distributed into 1 ml. ampoules and sterilized by autoclaving at 121°C. for 20 minutes. There is thus obtained a 2.0% solution of 2-(o-ethoxyphenoxymethyl)morpholine suitable for injection.

Workup

  1. additionis added slowly to this solution
  2. filtrationThe solution is filtered through a 5μ millipore membrane

Sources & evidence

ORD record
ord-8fcc49fe4266437eab1eb0cc31e7ee0c
Source dataset
uspto-grants-1976_05
Patent number
US03959273

Reaction notes

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