Acetone → 2,2,6,6-Tetramethyl-4-piperidone

HRID 1077005Notes

Reaction equation

HRID 1077005 reaction equation
[CH3:1][C:2]1[CH2:7][C:6]([CH3:9])([CH3:8])[NH:5][C:4]([CH3:11])([CH3:10])N=1.[Br-].[NH4+].CC(C)=[O:16]>O>[CH3:10][C:4]1([CH3:11])[NH:5][C:6]([CH3:9])([CH3:8])[CH2:7][C:2](=[O:16])[CH2:1]1

Participants

5

Reactant 3

HCID 180AcetoneHCID 25514Ammonium BromideHCID 68396Pyrimidine, 1,2,5,6-tetrahydro-2,2,4,6,6-pentamethyl-

Product 1

HCID 132202,2,6,6-Tetramethyl-4-piperidone

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

5.0 g. of Acetonine and 3.2 g. of ammonium bromide were heated at 44°C. for 15 hours in a mixed solvent comprising acetone and water in various ratios as shown hereinbelow to effect the reaction. After completion of the reaction, the reaction mixture was purified in the same manner as in Example 5 to obtain triacetonamine in a yield as shown hereinbelow.

Workup

  1. customthe reaction
  2. customAfter completion of the reaction
  3. customthe reaction mixture was purified in the same manner as in Example 5

Sources & evidence

ORD record
ord-a4f25fe6529c4151aa3cb1aae7419dea
Source dataset
uspto-grants-1976_05
Patent number
US03959298

Reaction notes

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