反应详情

A solution of 21-bromo-3α-hydroxy-5α-pregnane-11,20-dione (0.75 g.) in acetone (50 ml.) was treated with a solution of barium thiocyanate (2.6 g.) in water (10 ml.). The resulting mixture was refluxed for 4 hr., cooled and then partitioned between water and ether. The organic layer was washed with water, dried (Na2SO4) and evaporated. The residue (720 mg.) was purified by preparative t.l.c. (EtOAc) to afford title compound (685 mg.) as a white foam, [α]D + 67°.

1. temperatureThe resulting mixture was refluxed for 4 hr
2. temperature, cooled
3. custompartitioned between water and ether
4. washThe organic layer was washed with water
5. dry with materialdried (Na2SO4)
6. customevaporated
7. customThe residue (720 mg.) was purified by preparative t.l.c