Citric Acid → HCID 86733471, compound

Participants

Reaction Steps

A mixture of 21-morpholinoacetylthio-3α -hydroxy-5α-pregnane-11,20 -dione (245.8 mg., 0.5 mmole) and 0.1 M aqueous citric acid (10 ml., 1.0 mmole) was shaken vigorously for 30 minutes. The undissolved solid (138 mg.) was removed by filtration and the filtrate was assumed to contain 107 mg. of free steroidal base as its citrate in 10 ml. of solution. The filtrate was therefore an approximately 1% aqueous solution of the title compound.

Provenance & Evidence