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HRID1077024

反应详情

EQUATION

反应方程式

HRID 1077024 的结构方程式

REACTANTS

反应物

2
结构：C[C@]12CCC(=O)C[C@@H]1CC[C@H]1[C@@H]3CC[C@H](C(=O)CBr)[C@@]3(C)CC(=O)[C@@H]12
HCID86733474

未命名化合物

结构：OC(=S)CN1CCOCC1
HCID178526202

未命名化合物

PRODUCTS

生成物

1
结构：C[C@]12CCC(=O)C[C@@H]1CC[C@H]1[C@@H]3CC[C@H](C(=O)CSC(=O)CN4CCOCC4)[C@@]3(C)CC(=O)[C@@H]12
HCID86733475

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)=O
溶剂HCID180

Acetone

C3H6O

PROCEDURE

实验过程

21-Bromo-5α-pregnane-3,11,20-trione (1.04 g.) was refluxed in dry acetone (100 ml) with morpholino thioacetic acid (600 mg) for 15 minutes. The reaction mixture was concentrated, partitioned between ethyl acetate, water, pH 8, the organic layer was washed, dried (MgSO4) and evaporated to an off white solid (1.26g.)

WORKUP

后处理

  1. concentrationThe reaction mixture was concentrated
  2. custompartitioned between ethyl acetate, water, pH 8
  3. washthe organic layer was washed
  4. dry with materialdried (MgSO4)
  5. customevaporated to an off white solid (1.26g.)