HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl ether 2-propanol → 2-Pyrrolidino-6-methyl-4-(3-nitrophenyl)-4,5-dihydropyridine-3,5-dicarboxylic acid 3-ethyl ester-5-methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl ether 2-propanol | HCID 22147583 | — |
| Reactant | 3-Nitrobenzylideneacetoacetic acid methyl ester | HCID 53443010 | — |
| Reactant | 3-Pyrrolidino-3-aminoacrylic acid ethyl ester | HCID 70608008 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Pyrrolidino-6-methyl-4-(3-nitrophenyl)-4,5-dihydropyridine-3,5-dicarboxylic acid 3-ethyl ester-5-methyl ester | HCID 70608214 | 74% |
Reaction Steps
Boiling a solution of 12.5 g of 3-nitrobenzylideneacetoacetic acid methyl ester and 9.2 g of 3-pyrrolidino-3-aminoacrylic acid ethyl ester in 100 ml of ethanol for 2 hours yields 2-pyrrolidino-6-methyl-4-(3-nitrophenyl)-4,5-dihydropyridine-3,5-dicarboxylic acid 3-ethyl ester-5-methyl ester of melting point 103°C (isopropanol/ether). Yield: 74% of theory.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03959292 |
| Source dataset | uspto-grants-1976_05 |
| ORD ID | ord-b5d66469bb5444a197e54f4c5d27921c |
| Source note | uspto-grants-1976_05 |