HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Nitrobenzaldehyde → 2-Pyrrolidino-6-methyl-4-(3-nitrophenyl)-5-acetyl-4,5-dihydropyridine-3-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Nitrobenzaldehyde | HCID 7449 | — |
| Reactant | Acetylacetone | HCID 31261 | — |
| Reactant | Diethyl ether 2-propanol | HCID 22147583 | — |
| Reactant | 3-Pyrrolidino-3-aminoacrylic acid ethyl ester | HCID 70608008 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Pyrrolidino-6-methyl-4-(3-nitrophenyl)-5-acetyl-4,5-dihydropyridine-3-carboxylic acid ethyl ester | HCID 70608094 | 44% |
Reaction Steps
Heating a solution of 7.6 g of 3-nitrobenzaldehyde, 5.0 g of acetylacetone and 9.2 g of 3-pyrrolidino-3-aminoacrylic acid ethyl ester in 50 ml of ethanol for 2 hours yields 2-pyrrolidino-6-methyl-4-(3-nitrophenyl)-5-acetyl-4,5-dihydropyridine-3-carboxylic acid ethyl ester of melting point 130°C (isopropanol/ether). Yield: 44% of theory.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03959292 |
| Source dataset | uspto-grants-1976_05 |
| ORD ID | ord-5a589c6ea99e461eb862d933a3f40c22 |
| Source note | uspto-grants-1976_05 |