HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 2-Dimethylamino-6-methyl-4-(3-nitrophenyl)-4,5-dihydropyridine-3,5-dicarboxylic acid 3-ethyl ester-5-methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | 3-Nitrobenzylideneacetoacetic acid methyl ester | HCID 53443010 | — |
| Reactant | 3-Amino-3-dimethylaminoacrylic acid ethyl ester | HCID 86733464 | — |
| Product | 2-Dimethylamino-6-methyl-4-(3-nitrophenyl)-4,5-dihydropyridine-3,5-dicarboxylic acid 3-ethyl ester-5-methyl ester | HCID 70608074 | 54% |
Reaction Steps
Boiling a solution of 12.5 g of 3-nitrobenzylideneacetoacetic acid methyl ester and 8.2 g of 3-amino-3-dimethylaminoacrylic acid ethyl ester in 100 ml of ethanol for 2 hours yields 2-dimethylamino-6-methyl-4-(3-nitrophenyl)-4,5-dihydropyridine-3,5-dicarboxylic acid 3-ethyl ester-5-methyl ester of melting point 95°C (isopropanol). Yield: 54% of theory.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03959292 |
| Source dataset | uspto-grants-1976_05 |
| ORD ID | ord-25e3e7f26bdf4ae3bc4fc45fd42922f5 |
| Source note | uspto-grants-1976_05 |