HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 2-Pyrrolidino-4,6-dimethyl-4,5-dihydropyridine-3,5-dicarboxylic acid diethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Ethylideneacetoacetic acid ethyl ester | HCID 53428592 | — |
| Reactant | 3-Pyrrolidino-3-aminoacrylic acid ethyl ester | HCID 70608008 | — |
| Product | 2-Pyrrolidino-4,6-dimethyl-4,5-dihydropyridine-3,5-dicarboxylic acid diethyl ester | HCID 70608273 | 42% |
Reaction Steps
Boiling a solution of 7.8 g of ethylideneacetoacetic acid ethyl ester and 9.2 g of 3-pyrrolidino-3-aminoacrylic acid ethyl ester in 100 ml of ethanol for 2 hours and distilling the residue yields 2-pyrrolidino-4,6-dimethyl-4,5-dihydropyridine-3,5-dicarboxylic acid diethyl ester of boiling point (1.5 mm. Hg : 199° - 204°C). Yield: 42% of theory.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03959292 |
| Source dataset | uspto-grants-1976_05 |
| ORD ID | ord-62f2a39d365f42a9b25b3b5eeb63be01 |
| Source note | uspto-grants-1976_05 |