HuagongsheHuagongshe Chemistry Print Report · For research reference only
Naphth-1-ylmethylideneacetoacetic acid ethyl ester → 2-Pyrrolidino-6-methyl-4-naphth-1-yl-4,5-dihydropyridine-3,5-dicarboxylic acid diethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Naphth-1-ylmethylideneacetoacetic acid ethyl ester | HCID 54218022 | — |
| Reactant | 3-Pyrrolidino-3-aminoacrylic acid ethyl ester | HCID 70608008 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Pyrrolidino-6-methyl-4-naphth-1-yl-4,5-dihydropyridine-3,5-dicarboxylic acid diethyl ester | HCID 70607750 | 52% |
Reaction Steps
Boiling a solution of 13.4 g of naphth-1-ylmethylideneacetoacetic acid ethyl ester and 9.2 g of 3-pyrrolidino-3-aminoacrylic acid ethyl ester in 100 ml of ethanol for 2 hours yields 2-pyrrolidino-6-methyl-4-naphth-1-yl-4,5-dihydropyridine-3,5-dicarboxylic acid diethyl ester of melting point 121°C (ethanol). Yield: 52% of theory.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03959292 |
| Source dataset | uspto-grants-1976_05 |
| ORD ID | ord-1fa800d546ff42c78faf5136dfab8fa2 |
| Source note | uspto-grants-1976_05 |