N,N-Diethylethylenediamine → HCID 68129580, compound

HRID 1077036Notes

Reaction equation

HRID 1077036 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:10]([C:11]2[CH:16]=[CH:15][C:14](Cl)=[C:13]([N+:18]([O-:20])=[O:19])[CH:12]=2)[C:9]([C:21]([O:23][CH3:24])=[O:22])=[C:8]([CH3:25])[NH:7][C:6]=1[CH3:26])=[O:4].[CH2:27]([N:29]([CH2:33][CH3:34])[CH2:30][CH2:31][NH2:32])[CH3:28]>CCOCC>[CH3:1][O:2][C:3]([C:5]1[CH:10]([C:11]2[CH:16]=[CH:15][C:14]([NH:32][CH2:31][CH2:30][N:29]([CH2:33][CH3:34])[CH2:27][CH3:28])=[C:13]([N+:18]([O-:20])=[O:19])[CH:12]=2)[C:9]([C:21]([O:23][CH3:24])=[O:22])=[C:8]([CH3:25])[NH:7][C:6]=1[CH3:26])=[O:4]

Participants

4

Reactant 2

HCID 60993N,N-DiethylethylenediamineHCID 356264HCID 356264, compound

Product 1

HCID 68129580HCID 68129580, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Ten grams of 2,6-dimethyl-4-(3-nitro-4-chlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid dimethyl ester and 8 g of 2-(diethylamino)ethylamine are heated to 100° (external temperature) overnight. After cooling, ether is added and the product collected by filtration to yield orange crystals of melting point 161°C after recrystallization from 80 ml of methanol. Yield: 80% of theory.

Workup

  1. temperatureAfter cooling
  2. filtrationthe product collected by filtration
  3. customto yield orange crystals of melting point 161°C
  4. customafter recrystallization from 80 ml of methanol

Sources & evidence

ORD record
ord-08b0613fe331485ab9231bded0b1fa53
Source dataset
uspto-grants-1976_05
Patent number
US03959296

Reaction notes

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