Isobutyl chloroformate → 2-Naphthol

Participants

Reaction Steps

Following the procedure of Example 1 but using 0.535 g. of PGF2 α , 0.254 ml. of triethylamine, 0.238 ml. of isobutylchloroformate, and 0.327 g. of β-naphthol, there is obtained a crude residue. This residue is subjected to silica gel chromatography, eluting with ethyl acetate followed by acetonitrile. The residue obtained by concentration of selected fractions, 0.410 g., is crystallized from ethyl acetate diluted with 1.5 volumes of hexane as the title compound, white free-flowing crystals, m.p. 98.8°-100° C. having Rf 0.25 (TLC on silica gel in ethyl acetate).

Provenance & Evidence