反应详情

A mixture consisting of 0.3 gm (about 0.0015 mol) of 1-(2'-cyano-phenoxy)-2-hydroxy-3-amino-propane, 5 ml of absolute ethanol, 0.21 gm (0.002 mol) of sodium carbonate, 30 mgm of potassium iodide and 0.189 gm (0.002 mol) of propylene chlorohydrin was refluxed for 20 hours, accompanied by stirring. Thereafter, the reaction mixture was worked up in conventional manner, and the isolated raw reaction product was purified by chromatography in a silicagel column, yielding the free base 1-(2'-cyano-phenoxy)-2-hydroxy-3-[(2"-methyl-2"-hydroxy-ethyl)-amino]-propane.

1. temperaturewas refluxed for 20 hours
2. customthe isolated raw
3. customreaction product
4. customwas purified by chromatography in a silicagel column