Dimethyl Sulfoxide → HCID 86733465, compound

Participants

Reaction Steps

p-Bromomethyl benzoyl choline bromide (102 mg.) sodium bicarbonate (24.8 mg.) and dimethylsulfoxide (0.3 ml.) are heated in an oil bath at 125° for about 5 minutes until vigorous effervescence ceases. The solution is cooled giving a suspension which upon dilution with 2 ml. of water is dissolved. The addition of 5 ml. of absolute ethanol at room temperature yields a crystalline precipitate which is isolated by centrifugation. The solid is isolated, and dried in vacuo at 75° to yield a crisp glassy solid of hygroscopic character having spectral characteristics indicating the structure of p-formylbenzoyl choline iodide. In accordance with the foregoing procedure but starting with

Provenance & Evidence