HCID 21517622, compound → HCID 131710038, compound

Participants

Reaction Steps

4-(4-phenyl-2-oxobutylsulphinyl)-1-(1 -t-butoxycarbonyl-1-triphenylphosphoranylidenemethyl)-3-(triphenylmethyl-amino) azetidin-2-one (200 mg) was refluxed in dry dioxan (5 ml) under nitrogen for 8 hours. The mixture was evaporated to give a foam. The crude foam was chromatographed on silica gel eluting with ethyl acetate/petroleum ether mixtures to give t-butyl 3-β-phenylethyl-7-triphenylmethylamino-3-cephem-4-carboxylate-1-oxide as a yellow solid (87 mg).

Provenance & Evidence