Diethyl Ether → HCID 131710054, compound

HRID 1077102Notes

Reaction equation

F[C:2]1[CH:33]=[CH:32][C:5]([CH2:6][C:7]2[CH2:8][S:9][C@@H:10]3[CH:21]([NH:22][C:23](=[O:30])[CH2:24][C:25]4[S:26][CH:27]=[CH:28][CH:29]=4)[C:20](=[O:31])[N:11]3[C:12]=2[C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])=C[CH:3]=1.CC[O:36]CC>>[O:36]1[CH2:3][CH2:2][CH2:33][CH2:32][CH:5]1[CH2:6][C:7]1[CH2:8][S:9][C@@H:10]2[CH:21]([NH:22][C:23](=[O:30])[CH2:24][C:25]3[S:26][CH:27]=[CH:28][CH:29]=3)[C:20](=[O:31])[N:11]2[C:12]=1[C:13]([O:15][C:16]([CH3:18])([CH3:17])[CH3:19])=[O:14]

Participants

Reactant 2

HCID 3283Diethyl Ether

HCID 131710050HCID 131710050, compound2×

Product 1

HCID 131710054HCID 131710054, compound

Procedure

Trituration of the oil with ether gave the cephem (X) as a white solid (29 mg), m.p. 175°-185° decomp. M+ m/e 478 (parent peak) and the fragmentations expected for the cephem (X).

Sources & evidence

ORD record: ord-8a5ecb162fa7458c93d17c9aab864ffb
Source dataset: uspto-grants-1976_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03959267

Reaction notes

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