Formaldehyde → HCID 21485425, compound

Participants

Reaction Steps

Maintain 5-phenylpent-1-yne (20 g) for 12 hours at 70° under nitrogen with water (6.2 cc), trioxan (1.2 g), 30% formalin (13.8 g), diethylamine (10 g), acetic acid (6.9 g), dioxan (62 cc) and cuprous chloride (0.35 g). Make the cooled solution alkaline with sodium hydroxide. Extract with ether and extract the ether extract itself with hydrochloric acid. Make the purified aqueous hydrochloride solution thus obtained alkaline again and extract with ether. Dry, evaporate the ether extracts and distil the residue to obtain 1-diethylamino-6-phenylhex-2-yne (27.1 g), b.p. 104-106°/0.2 mm.

Provenance & Evidence