HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-(6-m-Methoxyphenyl-3-oxohexyl)-2-methylcyclopentane-1,3-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2-Methyl-1,3-cyclopentanedione | HCID 13005 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | 1-(Diethylamino)-6-(3-methoxyphenyl)hexan-3-one | HCID 21485504 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Sodium chloride; water | HCID 57417360 | — |
| Product | 2-(6-m-Methoxyphenyl-3-oxohexyl)-2-methylcyclopentane-1,3-dione | HCID 20350002 | — |
Reaction Steps
Add the crude methiodide of 1-diethylamino-6-m- methoxyphenylhexan-3-one (2.5 g) in methanol (10 cc) ice-cold to a solution obtained by adding 2-methylcyclopentane-1,3-dione (0.5 g) to an ice-cold solution of sodium (0.21 g) in methaol (10 cc). Allow the reaction mixture to warm to room temperature and leave for 16 hours, after which add N hydrochloric acid (10 cc) and saturated brine (100 cc), and ether-extract the solution. Evaporate the washed and dried extracts to obtain the crude adduct 2-(6-m-methoxyphenyl-3-oxohexyl)-2-methylcyclopentane-1,3-dione as a gum.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03959322 |
| Source dataset | uspto-grants-1976_05 |
| ORD ID | ord-e513a7a5ed3f408dbcb7f7cd2f449b49 |
| Source note | uspto-grants-1976_05 |