反应详情

Add a mixture of 1-diethylamino-6-(m-methoxyphenyl)-5-methylhexan-3-one and 5-methyl-6-(m-methoxyphenyl)hex-1-en-3-one (6 g, prepared by slow distillation of the former substance) to 2-ethylcyclopentane-1,3-dione (3.5 g) in 0.12% methanolic potassium hydroxide (10 cc) and heat the mixture under reflux for 6 hours. Remove most of the solvent under reduced pressure and add ether (25 cc) and benzene (25 cc) to the residue. Wash the solution with 5% aqueous sodium hydroxide, water, dilute hydrochloric acid, and brine, and dry. Evaporate the solvent to obtain a viscous brown gum, which is the triketone 2-ethyl-2-(6-m-methoxyphenyl-5-methyl-3-oxohexyl)cyclopentane-1,3-dione.

1. additionAdd
2. temperatureheat the mixture
3. temperatureunder reflux for 6 hours
4. customRemove most of the solvent under reduced pressure
5. additionadd ether (25 cc) and benzene (25 cc) to the residue
6. washWash the solution with 5% aqueous sodium hydroxide, water, dilute hydrochloric acid, and brine
7. customdry
8. customEvaporate the solvent
9. customto obtain a viscous brown gum, which