反应详情

Reflux a mixture of 2-cetylcyclopentane-1,3-dione (10.1 g), 6-m-methoxyphenylhex-1-en-3-one (6.0 g) and 0.02% methanolic potassium hydroxide solution (120 cc) for 26 hours and then cool. Dissolve the residue obtained after removal of solvent under reduced pressure in a mixture of benzene (50 cc) and ether (50 cc), and wash the solution in turn with sodium carbonate solution, 10% aqueous sulfuric acid and water. Remove the solvent by evaporation under reduced pressure to obtain as residue crude 2-cetyl-2-(6-m-methoxyphenyl-3-oxohexyl)-1,3-cyclopentanedione (11.4 g).

1. temperatureReflux
2. temperaturecool
3. dissolutionDissolve the residue
4. customobtained
5. customafter removal of solvent under reduced pressure
6. additionin a mixture of benzene (50 cc) and ether (50 cc)
7. washwash the solution in turn with sodium carbonate solution, 10% aqueous sulfuric acid and water
8. customRemove the solvent
9. customby evaporation under reduced pressure