Acetylene → HCID 86733488, compound

Participants

Reaction Steps

Stir dl-13-ethyl-3-methoxy-6-methylgona-2,5(10)-dien-17-one (3.6 g) in dimethylacetamide (35 cc) in a stream of acetylene for one-half hour. Add lithium acetylide-ethylenediamine (2.7 g) and stir for four hours. Pour into ice water, extract with ether and isolate the dl-13-ethyl-3-methoxy-17α-ethynyl-17β-hydroxy-6-methylgona-2,5(10)-diene as a gum (3.5 g), λ max. NaCl 2.90 μ, 3.05 μ, 5.90 μ, 6.03 μ.

Provenance & Evidence