HRID1077222

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID176

Acetic Acid

C2H4O2

HCID4311764

Sodium borohydride (Na(BH4))

H4BNa

结构：CC[C@]12CC[C@@H]3c4ccc(OC)cc4C(C)C[C@H]3[C@@H]1CCC2=O

HCID68143405

未命名化合物

PRODUCTS

生成物

结构：CC[C@]12CC[C@@H]3c4ccc(OC)cc4C(C)C[C@H]3[C@@H]1CC[C@@H]2O

HCID68144444

未命名化合物

收率 96.5%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

溶剂HCID57417360

Sodium chloride; water

ClH2NaO

PROCEDURE

实验过程

Dissolve dl-3-methoxy-6-methyl-13-ethylgona-1,3,5(10)-trien-17-one (7.0 g) in methanol (300 cc) and treat with sodium borohydride (3.0 g). After spontaneous reflux ceases, make acid with 50% aqueous acetic acid (20 cc). Pour into brine, extract with acid and isolate the dl-3-methoxy-17β-hydroxy-6-methyl-13-ethylgona-1,3,5(10)-triene (6.8 g), m.p. 150°-160°C, λ max. KBr 3.05, 6.45 μ.

WORKUP

后处理

temperatureAfter spontaneous reflux ceases
extractionextract with acid