HCID 21536144, compound → Methyl 4-hydroxy-2-methoxybenzoate

HRID 1077277Notes

Reaction equation

HRID 1077277 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[C:11]([O:13]C(=O)C2C=CC=CC=2)[CH:10]=[CH:9][C:4]=1[C:5]([O:7][CH3:8])=[O:6]>[Ni]>[CH3:1][O:2][C:3]1[CH:12]=[C:11]([OH:13])[CH:10]=[CH:9][C:4]=1[C:5]([O:7][CH3:8])=[O:6]

Participants

3

Reactant 1

HCID 21536144HCID 21536144, compound

Product 1

HCID 12532676Methyl 4-hydroxy-2-methoxybenzoate

Reagents, catalysts & solvents 1

HCID 935NickelCatalyst2×

Procedure

The product obtained in Stage B is hydrogenated in an autoclave in the presence of alcohol with Raney nickel as catalyst. The hydrogenation is done at 50° C and lasts 21/2 hours. It is cooled, the nickel drained and the alcohol removed under vacuum. The methyl 2-methoxy-4-hydroxybenzoate formed crystallizes and is used for the following stage.

Workup

  1. customis done at 50° C
  2. custom2 hours
  3. temperatureIt is cooled
  4. customthe alcohol removed under vacuum

Sources & evidence

ORD record
ord-9b6c87ce3fe64748a8d9ab00b9d1964d
Source dataset
uspto-grants-1976_05
Patent number
US03959477

Reaction notes

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