Formaldehyde → HCID 54013306, compound

HRID 1077300Notes

Reaction equation

HRID 1077300 reaction equation
[CH3:1][NH:2][C:3]([CH2:5][O:6][C:7]1[CH:22]=[CH:21][CH:20]=[CH:19][C:8]=1[O:9][CH2:10][CH:11]([OH:18])[CH2:12][NH:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:4].[CH2:23]=O>C(O)C>[CH3:1][NH:2][C:3]([CH2:5][O:6][C:7]1[CH:22]=[CH:21][CH:20]=[CH:19][C:8]=1[O:9][CH2:10][CH:11]1[O:18][CH2:23][N:13]([C:14]([CH3:17])([CH3:15])[CH3:16])[CH2:12]1)=[O:4]

Participants

4

Reactant 2

HCID 712FormaldehydeHCID 53698Cetamolol

Product 1

HCID 54013306HCID 54013306, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 1.3 g. of 3-(o-N-methylcarbamoylmethoxyphenoxy)-1-t-butylaminopropan-2-ol, 20 ml. of absolute ethanol and 2 ml. of aqueous 36% w/v formaldehyde solution is heated under reflux for 24 hours. The solution is evaporated to dryness under reduced pressure and there is thus obtained as the residual oil 5-(o-N-methylcarbamoylmethoxyphenoxymethyl)-3-t-butyloxazolidine which is characterised by its proton magnetic resonance spectrum.

Workup

  1. additionA mixture of 1.3 g
  2. temperatureis heated
  3. temperatureunder reflux for 24 hours
  4. customThe solution is evaporated to dryness under reduced pressure and there

Sources & evidence

ORD record
ord-91b96e201f084b8ca7efb9d47ea00510
Source dataset
uspto-grants-1976_05
Patent number
US03959486

Reaction notes

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