反应详情

A mixture of 3 g. (0.0156 mole) of 2-chloro-6-ethylaniline hydrochloride and 1.35 g. (0.016 mole) of cyanoguanidine in 25 ml of m-cresol is heated on a steam bath for 1 hour. The reaction mixture is then cooled and 250 ml of ether is added. The preciptate is filtered off and dissolved in 100 ml of warm water, charcoaled and filtered and cooled in an ice bath. 10% sodium hydroxide solution is then added to make the mixture strongly basic. The mixture is then filtered and washed with water. This is then dissolved in methanol, the pH is adjusted to 7 with methanolic hydrochloric acid and the mixture evaporated to dryness, triturated with ether and filtered to obtain 1-(2-chloro-6-ethylphenyl)biguanide hydrochloride (m.p. 209°-210°C).

1. additionA mixture of 3 g
2. temperatureThe reaction mixture is then cooled
3. filtrationThe preciptate is filtered off
4. dissolutiondissolved in 100 ml of warm water
5. filtrationfiltered
6. temperaturecooled in an ice bath
7. addition10% sodium hydroxide solution is then added
8. filtrationThe mixture is then filtered
9. washwashed with water
10. dissolutionThis is then dissolved in methanol
11. customthe mixture evaporated to dryness
12. customtriturated with ether
13. filtrationfiltered