Ethyl chloroformate → HCID 12319422, compound

HRID 1077321Notes

Reaction equation

HRID 1077321 reaction equation
C([N:8]1[CH2:13][CH2:12][C:11]2([C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:15]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[O:14]2)[CH2:10][CH2:9]1)C1C=CC=CC=1.Cl[C:29]([O:31][CH2:32][CH3:33])=[O:30]>C1C=CC=CC=1>[CH2:32]([O:31][C:29]([N:8]1[CH2:13][CH2:12][C:11]2([C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:15]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[O:14]2)[CH2:10][CH2:9]1)=[O:30])[CH3:33]

Participants

4

Reactant 2

HCID 10928Ethyl chloroformateHCID 12319396HCID 12319396, compound

Product 1

HCID 12319422HCID 12319422, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A solution of 7.7 g. of 1'-benzyl-1,3-dihydro-3-phenylspiro[isobenzofuran-1,4'-piperidine] (Example 4), 40 ml. of benzene and 2.5 ml. of ethyl chloroformate is heated under reflux for 18 hours and concentrated to a solid. Recrystallization from cyclohexane provides colorless crystals, m.p. 115°-119°.

Workup

  1. temperatureunder reflux for 18 hours
  2. concentrationconcentrated to a solid
  3. customRecrystallization from cyclohexane
  4. customprovides colorless crystals, m.p. 115°-119°

Sources & evidence

ORD record
ord-8514b6642df34ad5be6390dce024e105
Source dataset
uspto-grants-1976_05
Patent number
US03959475

Reaction notes

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