Hydrogen Bromide → HCID 12319402, compound

Participants

Reaction Steps

A solution of 3.5 g. of 1,3-dihydro-3-(4-methoxyphenyl)-1'-methylspiro[isobenzofuran-1,4'-piperidine], (Example 12), and 20 ml. of 48% hydrobromic acid is heated under reflux, cooled, diluted with water, neutralized with sodium bicarbonate, and extracted with chloroform. The chloroform solution is dried over magnesium sulfate and concentrated to an oil. Trituration with ether provides crystals, m.p. 132°dec. Recrystallization raises the melting point to 273°dec.

Provenance & Evidence