Hydrogen Bromide → HCID 12319449, compound

Participants

Reaction Steps

A suspension of 2.0 g. of 1,3-dihydro-6-methoxy-3-phenylspiro[isobenzofuran-1,4'-piperidine], (Example 73), and 32 ml. of a 48% hydrobromic acid solution is heated at reflux, effecting the separation of a hydrobromide salt as a crystalline precipitate. The mixture is poured into ice-water with stirring, the precipitate collected by filtration, the filter cake washed with water, and dried. Recrystallization from ethanol gives colorless crystals, m.p. 274°-276°, dec.

Provenance & Evidence