1′-(Phenylmethyl)spiro[isobenzofuran-1(3H),3′-piperidin]-3-one → HCID 21536121, compound

HRID 1077330Notes

Reaction equation

HRID 1077330 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][CH2:11][C:10]2([C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[C:15](=O)[O:14]2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:23]1([Li])[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[CH2:1]([N:8]1[CH2:13][CH2:12][CH2:11][C:10]2([C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[C:15]([C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[O:14]2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 122130861′-(Phenylmethyl)spiro[isobenzofuran-1(3H),3′-piperidin]-3-oneHCID 178506676HCID 178506676, compound

Product 1

HCID 21536121HCID 21536121, compound

Procedure

Reaction of 1'-benzyl-1,3-dihydrospiro[isobenzofuran-1,3'-piperidine]-3-one with a large excess of phenyllithium by the method described in Example 1 provides off-white crystals, m.p. 144°-146°.

Workup

  1. customprovides off-white crystals, m.p. 144°-146°

Sources & evidence

ORD record
ord-5d91c53c6ac44e3f883fd41f1f07d4a2
Source dataset
uspto-grants-1976_05
Patent number
US03959475

Reaction notes

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