反应详情

温度

120 °C

8 g 5-fluoro-2,4-diaminotoluene from Step 2 are dissolved in 250 ml pyridine, mixed with 7.9 ml benzenesulfonyl chloride, and stirred for 1 hour at 120° C. After cooling, the reaction preparation is poured over ice. The obtained precipitate is washed with water, dried in vacuum over phosphorus pentoxide, and recrystallized from methanol. 3.9 g (41% of theory) 5-fluoro-2,4-bis[(N-benzenesulfonyl)amino]toluene are obtained which melts at 146° C.

1. temperatureAfter cooling
2. customthe reaction preparation
3. additionis poured over ice
4. washThe obtained precipitate is washed with water
5. dry with materialdried in vacuum over phosphorus pentoxide
6. customrecrystallized from methanol