7-Dehydrocholesterol → Previtamin D3

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From the hexane data, it was concluded that the material eluted at 12.2 min is tachysterol. The size and kind of microreactor is important to the ratio of products formed. Where the microreactor is several times the size of the 7-DHC, the undesirable side reactions are more favored. For example the silica with 60 Å pores (Ex. 10 and 11) give a ratio of previtamin D3 :tachysterol similar to that of the reaction in hexane (Ex. 9). In micelles (Ex. 16), however, which form a similarly sized microreactor, but with an environment similar to that of a hydrocarbon solvent, tachysterol is very heavily favored.

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