Water → 3,5-Bis(trifluoromethyl)phenyl isothiocyanate

HRID 1077397Notes

Reaction equation

HRID 1077397 reaction equation
[C:1](Cl)(Cl)=[S:2].O.[F:6][C:7]([F:20])([F:19])[C:8]1[CH:9]=[C:10]([CH:12]=[C:13]([C:15]([F:18])([F:17])[F:16])[CH:14]=1)[NH2:11]>C(Cl)(Cl)Cl>[F:6][C:7]([F:19])([F:20])[C:8]1[CH:9]=[C:10]([N:11]=[C:1]=[S:2])[CH:12]=[C:13]([C:15]([F:16])([F:18])[F:17])[CH:14]=1

Participants

5

Reactant 3

HCID 962WaterHCID 9480Benzenamine, 3,5-bis(trifluoromethyl)-HCID 10040Thiophosgene

Product 1

HCID 27333953,5-Bis(trifluoromethyl)phenyl isothiocyanate

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

0.052 Mol of thiophosgene were mixed with 60 ml of water and were stirred for 15 minutes. 0.040 Mol of 3,5-bistrifluoromethylaniline were dropped with 30 ml chloroform, and the mixture was stirred for 2 hours at 15° C. The organic solution was washed with HCl 2M, dried and the solvent was removed under vacuum to obtain 3,5-bistrifluoromethylphenylisothiocyanate as a yellow-red oil, that was used as crude product.

Workup

  1. stirringthe mixture was stirred for 2 hours at 15° C
  2. washThe organic solution was washed with HCl 2M
  3. customdried
  4. customthe solvent was removed under vacuum

Sources & evidence

ORD record
ord-5da72f0a5e5d4ccfb0172368ad0cf772
Source dataset
uspto-grants-1996_08
Patent number
US05543278

Reaction notes

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