Sodium Hydroxide → HCID 54526402, compound

HRID 1077413Notes

Reaction equation

HRID 1077413 reaction equation
[CH:1]([C:4]1[C:8]([C:9]([O:11][CH3:12])=[O:10])=[C:7]([C:13]([O:15]C)=[O:14])[O:6][N:5]=1)([CH3:3])[CH3:2].[OH-].[Na+]>CO.O>[CH3:12][O:11][C:9]([C:8]1[C:4]([CH:1]([CH3:3])[CH3:2])=[N:5][O:6][C:7]=1[C:13]([OH:15])=[O:14])=[O:10]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 15066139HCID 15066139, compound

Product 1

HCID 54526402HCID 54526402, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent2×

Procedure

40 g of dimethyl 3-isopropylisoxazole-4,5-dicarboxylate are dissolved in 200 ml of methanol. A solution of 7.05 g of sodium hydroxide in 50 ml of water is added dropwise at 0° C. to this solution. It is stirred for 14 hours and allowed to warm to room temperature. The reaction selution is diluted with water and extracted twice with ethyl acetate. The alkaline solution is then acidified with conc. hydrochloric acid and extracted several times with ethyl acetate, and the organic phase is dried and concentrated.

Workup

  1. extractionextracted twice with ethyl acetate
  2. extractionextracted several times with ethyl acetate
  3. customthe organic phase is dried
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-0009820173a1467d9e530d432d9cdb9e
Source dataset
uspto-grants-1996_08
Patent number
US05543416

Reaction notes

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