Dimethyl Sulfoxide → 2-amino-5-[pyridazin-3(2H)-on-6-yl]indane hydrobromide

HRID 1077419ノート

反応式

HRID 1077419 の反応式
[BrH:1].C(O)(=O)C.[NH2:6][CH:7]1[CH2:15][C:14]2[C:9](=[CH:10][CH:11]=[C:12]([C:16]3[CH2:17][CH2:18][C:19](=[O:22])[NH:20][N:21]=3)[CH:13]=2)[CH2:8]1.CS(C)=O>C(OCC)C>[NH2:6][CH:7]1[CH2:15][C:14]2[C:9](=[CH:10][CH:11]=[C:12]([C:16]3[CH:17]=[CH:18][C:19](=[O:22])[NH:20][N:21]=3)[CH:13]=2)[CH2:8]1.[BrH:1]

参加物

5

反応物 3

HCID 679Dimethyl SulfoxideHCID 140714996-(2-amino-indan-5-yl)-4,5-dihydropyridazin-3(2H)-oneHCID 21893785Acetic Acid Mixture with Hydrobromic Acid

生成物 1

HCID 189297722-amino-5-[pyridazin-3(2H)-on-6-yl]indane hydrobromide

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

In 70 ml of a 25% hydrogen bromide-acetic acid solution was suspended 8.02 g of 2-amino-5-[4,5-dihydropyridazin-3(2H)-on-6-yl]indane, and 2.96 g of dimethyl sulfoxide was added to the suspension under ice cooling. The mixture was stirred at room temperature for 1.5 hours. Then, 140 ml of diethyl ether was added to the reaction mixture, and crystals precipitated were collected by filtration and recrystallized from methanol to obtain 8.55 g of 2-amino-5-[pyridazin-3(2H)-on-6-yl]indane·hydrobromide.

後処理

  1. additionwas added to the suspension under ice cooling
  2. customprecipitated
  3. filtrationwere collected by filtration
  4. customrecrystallized from methanol

出典と根拠

ORDレコード
ord-d630d0cdffa7473b925619ca2bb07c59
出典データセット
uspto-grants-1996_08
特許番号
US05543409

反応ノート

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