Sodium Hydroxide → 6-(2-amino-indan-5-yl)-4,5-dihydropyridazin-3(2H)-one

Participants

Reaction Steps

In 1.65 l of warm water was dissolved 138.8 g of optically active 2-amino-5-[4,5-dihydropyridazin-3(2H)-on6-yl]indane·(-)-camphorsulfonate. Under cooling, 13.05 g of sodium hydroxide dissolved in 130 ml of water was added dropwise to the solution, and the mixture was cooled for 2 hours. Crystals precipitated were collected by filtration, dried and then recrystallized from methanol to obtain 66.6 g of (+)-2-amino-5-[4, 5-dihydropyridazin-3(2H)-on-6-yl]indane.

Provenance & Evidence