Sodium Hydroxide → 141807-97-8

HRID 1077448Notes

Reaction equation

HRID 1077448 reaction equation
[NH2:1][C:2]1[N:7]([CH2:8][CH2:9][CH3:10])[C:6](=[O:11])[N:5]([CH2:12][CH2:13][CH3:14])[C:4](=[O:15])[C:3]=1[NH:16][C:17](=O)/[CH:18]=[CH:19]/[C:20]1[CH:25]=[C:24]([O:26][CH3:27])[C:23]([O:28][CH3:29])=[C:22]([O:30][CH3:31])[CH:21]=1.[OH-].[Na+]>O1CCOCC1>[CH2:12]([N:5]1[C:4](=[O:15])[C:3]2[NH:16][C:17](/[CH:18]=[CH:19]/[C:20]3[CH:25]=[C:24]([O:26][CH3:27])[C:23]([O:28][CH3:29])=[C:22]([O:30][CH3:31])[CH:21]=3)=[N:1][C:2]=2[N:7]([CH2:8][CH2:9][CH3:10])[C:6]1=[O:11])[CH2:13][CH3:14]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 18915205HCID 18915205, compound

Product 1

HCID 6448586141807-97-8Yield 91%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To 10.02 g (22.5 mmol) of Compound E were added 100 ml of dioxane and 100 ml of an aqueous 2N.sodium hydroxide solution, and the solution was heated under reflux for 10 minutes. After cooling, the solution was neutralized, and deposited crystals were collected by filtration. Then, the collected crystals were recrystallized from dioxane/water to give 6.83 g (yield 91%) of Compound 9 as white crystals.

Workup

  1. temperatureunder reflux for 10 minutes
  2. temperatureAfter cooling
  3. filtrationwere collected by filtration
  4. customThen, the collected crystals were recrystallized from dioxane/water

Sources & evidence

ORD record
ord-61e20d6f591e4d1db3cb0cb6eb2bf651
Source dataset
uspto-grants-1996_08
Patent number
US05543415

Reaction notes

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