5,6-Diamino-1,3-dipropyl-2,4(1H,3H)-pyrimidinedione → 151539-24-1

HRID 1077456Notes

Reaction equation

HRID 1077456 reaction equation
[NH2:1][C:2]1[C:3](=[O:16])[N:4]([CH2:13][CH2:14][CH3:15])[C:5](=[O:12])[N:6]([CH2:9][CH2:10][CH3:11])[C:7]=1[NH2:8].[CH2:17]([O:24][C:25]1[C:35]([O:36][CH3:37])=[CH:34][C:28](/[CH:29]=[CH:30]/[C:31](O)=O)=[CH:27][C:26]=1[O:38][CH3:39])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[CH2:17]([O:24][C:25]1[C:35]([O:36][CH3:37])=[CH:34][C:28](/[CH:29]=[CH:30]/[C:31]2[NH:1][C:2]3[C:3](=[O:16])[N:4]([CH2:13][CH2:14][CH3:15])[C:5](=[O:12])[N:6]([CH2:9][CH2:10][CH3:11])[C:7]=3[N:8]=2)=[CH:27][C:26]=1[O:38][CH3:39])[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 50986055,6-Diamino-1,3-dipropyl-2,4(1H,3H)-pyrimidinedioneHCID 11088319HCID 11088319, compound

Product 1

HCID 6448782151539-24-1Yield 74.4%

Procedure

Substantially the same procedure as in Reference Example 1 was repeated using 3.30 g (14.5 mmol) of 5,6-diamino-1,3-dipropyluracil and 5.0 g (15.9 mmol) of Compound H. Then, the resultant crude crystals were recrystallized from ethanol/2-propanol to give 5.44 g (yield 74%) of Compound 27 as a white powder.

Workup

  1. customThen, the resultant crude crystals were recrystallized from ethanol/2-propanol

Sources & evidence

ORD record
ord-88732182e0754ee8a8485fd9a7a4ca65
Source dataset
uspto-grants-1996_08
Patent number
US05543415

Reaction notes

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