3-(2,3,4-Trimethoxyphenyl)-2-propenoic acid → 1H-Purine-2,6-dione, 3,7-dihydro-1,3-diethyl-8-(2-(2,3,4-trimethoxyphenyl)ethenyl)-, (E)-

HRID 1077481Notes

Reaction equation

HRID 1077481 reaction equation
[NH2:1][C:2]1[C:3](=[O:14])[N:4]([CH2:12][CH3:13])[C:5](=[O:11])[N:6]([CH2:9][CH3:10])[C:7]=1[NH2:8].[CH3:15][O:16][C:17]1[C:27]([O:28][CH3:29])=[C:26]([O:30][CH3:31])[CH:25]=[CH:24][C:18]=1[CH:19]=[CH:20][C:21](O)=O>>[CH2:12]([N:4]1[C:3](=[O:14])[C:2]2[NH:1][C:21](/[CH:20]=[CH:19]/[C:18]3[CH:24]=[CH:25][C:26]([O:30][CH3:31])=[C:27]([O:28][CH3:29])[C:17]=3[O:16][CH3:15])=[N:8][C:7]=2[N:6]([CH2:9][CH3:10])[C:5]1=[O:11])[CH3:13]

Participants

3

Reactant 2

HCID 1184003-(2,3,4-Trimethoxyphenyl)-2-propenoic acidHCID 45721335,6-Diamino-1,3-diethyluracil

Product 1

HCID 64488551H-Purine-2,6-dione, 3,7-dihydro-1,3-diethyl-8-(2-(2,3,4-trimethoxyphenyl)ethenyl)-, (E)-Yield 57%

Procedure

Substantially the same procedure as in Reference Example 70 was repeated using 2.5 g (12.6 mmol) of 5,6-diamino-1,3-diethyluracil and 2.3 g (13.9 mmol) of 2,3,4-trimethoxycinnamic acid. Then, the resultant crude crystals were recrystallized from dioxane/water to give 2.85 g (yield 57% of Compound 79 as white crystals.

Workup

  1. customThen, the resultant crude crystals were recrystallized from dioxane/water

Sources & evidence

ORD record
ord-5111ddbc06b045aaa6c4bf4af33b7650
Source dataset
uspto-grants-1996_08
Patent number
US05543415

Reaction notes

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