Fluorocinnamic acid → 1,3-diethyl-8-[(E)-1-fluoro-2-phenylethenyl]-7H-purine-2,6-dione

HRID 1077509Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1077509
[NH2:1][C:2]1[C:3](=[O:14])[N:4]([CH2:12][CH3:13])[C:5](=[O:11])[N:6]([CH2:9][CH3:10])[C:7]=1[NH2:8].[F:15][C:16](=[CH:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[C:17](O)=O>>[CH2:12]([N:4]1[C:3](=[O:14])[C:2]2[NH:1][C:17](/[C:16](/[F:15])=[CH:20]\[C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)=[N:8][C:7]=2[N:6]([CH2:9][CH3:10])[C:5]1=[O:11])[CH3:13]

Komponenten

3

Edukt 2

HCID 98321Fluorocinnamic acidHCID 45721335,6-Diamino-1,3-diethyluracil

Produkt 1

HCID 208411351,3-diethyl-8-[(E)-1-fluoro-2-phenylethenyl]-7H-purine-2,6-dioneAusbeute 58 %

Versuchsvorschrift

Substantially the same procedure as in Reference Example 70 was repeated using 1.08 g (5.47 mmol) of 5,6-diamino-1,3-diethyluracil and 1.00 g (6.02 mmol) of α-fluorocinnamic acid. Then, the resultant crude crystals were recrystallized from dioxane/water to give 1.04 g (yield 58%) of Compound 137 as white plates.

Aufarbeitung

  1. customThen, the resultant crude crystals were recrystallized from dioxane/water

Quellen und Nachweise

ORD-Eintrag
ord-63d87a15a8e84b5db08886a9ffe0282e
Quelldatensatz
uspto-grants-1996_08
Patentnummer
US05543415

Notizen zur Reaktion

Wird geladen…