3-(2-Fluorophenyl)prop-2-enoic acid → 1H-Purine-2,6-dione, 3,7-dihydro-1,3-diethyl-8-(2-(2-fluorophenyl)ethenyl)-, (E)-

Participants

Reaction Steps

Substantially the same procedure as in Reference Example 70 was repeated using 2.70 g (13.6 mmol) of 5,6-diamino-1,3-diethyluracil and 2.49 g (15.0 mmol) of 2-fluorocinnamic acid. Then, the resultant crude crystals were recrystallized from dioxane/water to give 1.81 g (yield of Compound 167 as a white powder.

Provenance & Evidence