3-(3-Fluoro-4-methoxyphenyl)prop-2-enoic acid → 1H-Purine-2,6-dione, 3,7-dihydro-1,3-diethyl-8-(2-(3-fluoro-4-methoxyphenyl)ethenyl)-, (E)-

Participants

Reaction Steps

Substantially the same procedure as in Reference Example 70 was repeated using 2.50 g (12.6 mmol) of 5,6-diamino-1,3-diethyluracil and 2.72 g (13.9 mmol) of 3-fluoro-4-methoxycinnamic acid. Then, the resultant crude crystals were recrystallized from dioxane/water to give 1.97 g (yield 44%) of Compound 172 as pale yellow flocculent precipitates.

Provenance & Evidence