Water → (E)-8-(4-(4-bromobutoxy)styryl)-1,3-diethyl-7-methylxanthine

Participants

Role	Name	HCID	Charge
Reactant	Water	HCID 962	—
Reactant	1,4-Dibromobutane	HCID 8056	—
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	1H-Purine-2,6-dione, 3,7-dihydro-1,3-diethyl-8-(2-(4-hydroxyphenyl)eth enyl)-7-methyl-, (E)-	HCID 135665343	—
Solvent	Dimethylformamide	HCID 6228	—
Product	(E)-8-(4-(4-bromobutoxy)styryl)-1,3-diethyl-7-methylxanthine	HCID 6448951	61%

Reaction Conditions

Temperature	50 °C

Reaction Steps

Compound 184 (200 mg, 0.59 mmol) obtained in Reference Example 181 was dissolved in 4 ml of dimethylformamide. To the solution were added 163 mg (1.18 mmol) of potassium carbonate and 0.56 ml (1.18 mmol) of 1,4-dibromobutane, and the mixture was stirred at 50° C. for 4 hours. Water was added thereto under ice cooling to dissolve potassium carbonate and the deposited crystals were collected by filtration. The obtained crude crystals were recrystallized from hexane/ethyl acetate to give 170 mg (yield 61%) of Compound 186 as pale yellow grains.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05543415
Source dataset	uspto-grants-1996_08
ORD ID	ord-b32a33aa86374d798a09248b0643c89d
Source note	uspto-grants-1996_08