HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cycloleucine → 1-(Cbz-amino)cyclohexanecarboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cycloleucine | HCID 2901 | — |
| Reactant | Aminoisobutyric acid | HCID 6119 | — |
| Reactant | 1-Aminocycloheptanecarboxylic acid | HCID 23378 | — |
| Reactant | 1-Aminocyclobutanecarboxylic acid | HCID 89643 | — |
| Reactant | 1-Aminocyclooctane-1-carboxylic acid | HCID 95194 | — |
| Reactant | alpha-Amino-2-ethylbutanoic acid | HCID 95206 | — |
| Reactant | alpha,alpha-Di-n-butylglycine | HCID 95895 | — |
| Reactant | Dipropylglycine | HCID 97817 | — |
| Reactant | 2-Amino-2,2-dicyclopropylacetic acid | HCID 233600 | — |
| Reactant | 2-Amino-2-benzyl-3-phenylpropanoic acid | HCID 234515 | — |
| Reactant | 1-Amino-1-cyclodecanecarboxylic acid | HCID 4055273 | — |
| Reactant | Leucine, 2-(2-methylpropyl)- | HCID 12042141 | — |
| Reactant | 2-Amino-3-methyl-2-(propan-2-yl)butanoic acid | HCID 15160191 | — |
| Reactant | 2-Amino-2,2-biscyclobutylacetic acid | HCID 19431538 | — |
| Reactant | 1-Aminocyclononane-1-carboxylic acid | HCID 22326336 | — |
| Product | 1-(Cbz-amino)cyclohexanecarboxylic acid | HCID 11357886 | — |
Reaction Steps
In a similar manner, using 1-amino-cyclobutanecarboxylic acid, 1-amino-cyclopentanecarboxylic acid, 1-amino-cycloheptane-carboxylic acid, 1-amino-cyclooctanecarboxylic acid, 1-amino-cyclononanecarboxylic acid, 1-amino-cyclodecanecarboxylic acid, 2-amino-2-methylpropionic acid, 2-amino-2-ethylbutyric acid, 2-amino-2-n-propylvaleric acid, 2-amino-2-isopropyl-3-methylbutyric acid, 2-amino-2-isobutyl-4-methylvaleric acid, 2-amino-2-n-butylhexanoic acid, 2-amino-2,2-biscyclopropylacetic acid, 2-amino-2,2-biscyclobutylacetic acid or 2-amino-2,2-bisbenzylacetic acid instead of 1-amino-cyclohexanecarboxylic acid, the following starting materials are prepared:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05543414 |
| Source dataset | uspto-grants-1996_08 |
| ORD ID | ord-4c8f22ab17d94957a64d7917cff84994 |
| Source note | uspto-grants-1996_08 |