HCID 136333560, compound → Acetate

Participants

Reaction Steps

To a solution of 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediyl bis (N-benzyloxycarbonyl-1-amino-cyclohexanecarboxylate), 2.0 g (2.58 mmol) in glacial acetic acid (30 mL) was added palladium on carbon (10%, 0.5 g) and the mixture was hydrogenated under 1 atmosphere hydrogen overnight at room temperature. The mixture was filtered through Celite and the filtrate concentrated under reduced pressure to a thick oil. Water was added to the residue and the mixture was lyophilized to give 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediyl bis (1-amino-cyclohexanecarboxylate) as an acetate as a white solid. Mass spectrum: MA+ 506; Mw 505. Elemental Analysis: C29H47O12N7.1HOAc.1H2O. Calc.: C 49.49; H 7.02; N 13.93. Found: C 49.32; H 6.97; N 13.89.

Provenance & Evidence