Tetrabutylammonium Fluoride → HCID 10837375, compound

Participants

Reaction Steps

5 g of 3-trimethylsilylethoxycarbonylamino-6-benzyloxy-4-methoxymethyl-β-carboline in 40 ml of tetrahydrofuran is heated with 22 ml of tetrabutylammonium fluoride for 3 hours to 50° C. After distilling off the solvent it is taken up in ethyl acetate and washed once each with a saturated sodium-carbonate and saturated common salt solution. The organic phase is dried, filtered and concentrated by evaporation. The residue is chromatographed on silica gel with methylene chloride: ethanol=10:2 as eluant. After concentration by evaporation of the corresponding fractions and absorptive precipitation with cyclohexane/ethyl acetate, 1.32 g of 3-amino-6-benzyloxy-4-methoxymethyl-β-carboline is obtained.

Provenance & Evidence