Thioacetamide → HCID 19431928, compound

Participants

Reaction Steps

0.530 g of 6-benzyloxy-3-bromoacetyl-4-methoxymethyl-9-tosyl-β-carboline is refluxed for 3 hours in 50 ml of ethanol with 0.07 g of thioacetamide. After concentration by evaporation the residue is chromatographed on silica gel with cyclohexane and ethyl acetate=1+1 as eluant. 0,260 g of 6-benzyloxy-4-methoxymethyl-3-(2-methyl-4-thiazolyl)-9-tosyl-β-carboline of a melting point 181°-182° C. is obtained.

Provenance & Evidence