Hydrogen Bromide → HCID 131719482, compound

Participants

Reaction Conditions

Reaction Steps

Into a 15 mL culture tube was placed N-benzyl-(1R, 3R)-1,2,3,4-tetrahydro-6,8-dimethoxy-1,3-dimethylisoquinoline (62 mg, 0.2 mmol) dissolved in acetic acid (1 mL). To this solution were added sodium iodide (120 mg, 0.8 mmol) and concentrated aqueous hydrobromic acid (49%, 2 mL). The mixture was heated at 100° C. for 3 hours and then cooled to 0° C., at which time light yellow crystals precipitated out of solution. Vacuum filtration with a glass fritted Buchner funnel gave the N-benzyl-(1R, 3R)-1,2,3,4-tetrahydro-6,8-dihydroxy-1,3-dimethyl-isoquinoline hydrobromide salt [105] (48 mg, 66%) as light yellow crystals.

Provenance & Evidence