1-Phenethylamine, (+)- → HCID 54388353, compound

HRID 1077599Notes

Reaction equation

HRID 1077599 reaction equation
ClC[NH:3][CH2:4][Si:5]([CH3:8])([CH3:7])[CH3:6].[CH3:9][C@@H:10](N)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>[OH-].[K+]>[C:11]1([CH:10]([C@H:4]([NH2:3])[Si:5]([CH3:8])([CH3:7])[CH3:6])[CH3:9])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

4

Reactant 2

HCID 6431891-Phenethylamine, (+)-HCID 19431995HCID 19431995, compound

Product 1

HCID 54388353HCID 54388353, compound

Reagents, catalysts & solvents 1

HCID 14797Potassium HydroxideSolvent

Procedure

Chloromethyl(trimethylsilyl)methylamine (25 g, 0.166 mol) was treated under reflux with (R)-(+)-α-methylbenzylamine (78.5 mL, 0.61 mol) for 6 h. After cooling 100 mL of 15% KOH was added. The resulting solution was stirred before extracting twice with diethyl ether. The organics were combined and washed with brine and dried (K2CO3). The solvent was removed in vacuo and the residue was distilled at 0.001 mm Hg to give the title compound as a clear oil between 38°-45° C.

Workup

  1. additionwas added
  2. extractionbefore extracting twice with diethyl ether
  3. washwashed with brine
  4. dry with materialdried (K2CO3)
  5. customThe solvent was removed in vacuo
  6. distillationthe residue was distilled at 0.001 mm Hg

Sources & evidence

ORD record
ord-32b1e896e1c44916b2fad2e3c059d3e3
Source dataset
uspto-grants-1996_08
Patent number
US05543530

Reaction notes

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