HCID 57289350, compound → HCID 178460922, compound

Participants

Reaction Steps

10.0 ml (10.0 mmol) of a tetrahydrofuran solution of 1.0M 4-(trans-4-n-propyl-4-silacyclohexyl) phenylethyl zinc chloride was dripped into a mixture of 4.20 g (14.8 mmol) of 2,3-difluoro-4-iodoethoxybenzene, 70 mg of tetrakis (triphenylphosphine) palladium (0) and 15 ml of tetrahydrofuran. The reaction mixture was reacted for 2 hours at 50° C. After a conventional after treatment, purification was conducted by means of silica-gel column chromatography to obtain 3.25 g (yield 88%) of the target product.

Provenance & Evidence